IEEE Microbiota Of Inflammatory Bowel Disease Models 2018 RETAiL eBook iDiB

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  |  IEEE.Microbiota.Of.Inflammatory.Bowel.Disease.Models.2018.       |
  |  .RETAiL.eBook-iDiB                                               |
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         PACKS________: idib-mofbdm                                   
         RELEASE DATE_: 2019.07.06                                    
         YEAR_________: 2018                                          
         LANGUAGE_____: English                                       
         RELEASE SIZE_: 1 Mb - 01 files                               
         PAGES________: 4                                             
   
         SOURCE_______: https://ieeexplore.ieee.org/document/8512848  
         PROTECTION___: AmazonDRM(removed)                            
         FORMAT_______: .pdf                                          
   
         ISBN CODE____: 978-1-5386-3646-6                             
         GENRE________: Scientific papers                             
   
         NOTES________: Enjoy                                         
   
         PLOT_________: Abstract: Gut microbiome plays an important   
                        role in inflammatory bowel disease (IBD), a   
                        group of intestinal chronic inflammation      
                        conditions that affect a large population.    
                        The animal models of IBD have long been       
                        established on basis of pathological          
                        features, but their ability to recapitulate   
                        patient gut microbiota is unknown. We         
                        investigated and compared the composition and 
                        biodiversity of bacterial population in the   
                        fecal samples from rat models of the two IBD  
                        subtypes, and compared them with patient      
                        samples. Our analyses revealed that           
                        inflammation reduces overall microbiome       
                        diversity and increased variation between     
                        individuals. We identified specific microbial 
                        signatures associated with the two IBD        
                        subtypes that were consistent between the     
                        animal models and human IBD patients,         
                        suggesting that the animal models can         
                        partially recapitulate the microbiota in      
                        human diseases. Furthermore, metagenome       
                        prediction analysis suggested microbial       
                        functions that were likely altered by         
                        host-microbiota interactions in IBD models.   
   
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