IEEE Microbiota Of Inflammatory Bowel Disease Models 2018 RETAiL eBook iDiB | 1.7M | EBOOKS
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| IEEE.Microbiota.Of.Inflammatory.Bowel.Disease.Models.2018. |
| .RETAiL.eBook-iDiB |
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. .
PACKS________: idib-mofbdm
RELEASE DATE_: 2019.07.06
YEAR_________: 2018
LANGUAGE_____: English
RELEASE SIZE_: 1 Mb - 01 files
PAGES________: 4
SOURCE_______: https://ieeexplore.ieee.org/document/8512848
PROTECTION___: AmazonDRM(removed)
FORMAT_______: .pdf
ISBN CODE____: 978-1-5386-3646-6
GENRE________: Scientific papers
NOTES________: Enjoy
PLOT_________: Abstract: Gut microbiome plays an important
role in inflammatory bowel disease (IBD), a
group of intestinal chronic inflammation
conditions that affect a large population.
The animal models of IBD have long been
established on basis of pathological
features, but their ability to recapitulate
patient gut microbiota is unknown. We
investigated and compared the composition and
biodiversity of bacterial population in the
fecal samples from rat models of the two IBD
subtypes, and compared them with patient
samples. Our analyses revealed that
inflammation reduces overall microbiome
diversity and increased variation between
individuals. We identified specific microbial
signatures associated with the two IBD
subtypes that were consistent between the
animal models and human IBD patients,
suggesting that the animal models can
partially recapitulate the microbiota in
human diseases. Furthermore, metagenome
prediction analysis suggested microbial
functions that were likely altered by
host-microbiota interactions in IBD models.
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